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Abstract OBJECTIVE To investigate the relationships among obstructive sleep apnea (OSA), which is primarily characterized by the rapid eye movement (REM) phase, laboratory tests, cerebral infarction location, respiratory events and cerebral infarction clinical prognosis. METHODS: At the Department of Neurology at the Affiliated Hospital of Yangzhou University, a retrospective cohort study was performed to gather general data, routine blood, magnetic resonance, objective sleep data from the Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), and polysomnography (PSG), as well as prognostic indicators from the follow-up of patients with cerebral infarction from February 2022 to September 2023. Additionally, the association between the rapid eye movement apnea hypopnea index (REM-AHI) and clinical data was examined using linear regression, and the relationship between the prognosis of cerebral infarction and REM-OSA was examined using binary logistic regression. RESULTS: After screening 274 OSA patients with cerebral infarction (N = 229) with an AHI ≥ 5, the patients were divided into two groups: REM-OSA (N = 37, 16.2%) and NREM-OSA (N = 192, 83.8%). Multiple linear regression analysis revealed that leukocyte count, BMI and REM-AHI were linearly related. Binary logistic regression analysis revealed a relationship between the mRS score and REM-OSA, and the results of the t test indicated that the mRS score was lower in the cerebral infarction with REM-OSA group. CONCLUSION: The prognosis for cerebral infarction patients with REM-OSA is worse than that for patients with NREM-OSA, and the differences between NREM and REM potentially suggest a mechanistic difference.
Xu et al. (Mon,) studied this question.