⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

August 24, 2024MoleculesOpen Access

Synthesis and Biological Evaluation of Novel Piperidine-3-Carboxamide Derivatives as Anti-Osteoporosis Agents Targeting Cathepsin K

Yali Wang Ting Guan Hegen Xiong Wenxin Hu Xianjian Zhu Yuan‐Yuan Ma Zhiqing Zhang

View Full Paper

Ask AI

Bookmark

Share

Abstract

A series of novel piperidamide-3-carboxamide derivatives were synthesized and evaluated for their inhibitory activities against cathepsin K. Among these derivatives, compound

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Wang et al. (2024) studied this question.

synapsesocial.com/papers/68e5b130b6db64358754a221 https://doi.org/10.3390/molecules29174011

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Potent and Selective Ketoamide-Based Inhibitors of Cysteine Protease, Cathepsin KIn Vitro Study · 2004 · 12 citations
2A Novel Class of Nonpeptidic Biaryl Inhibitors of Human Cathepsin KIn Vitro Study · 2003 · 82 citations
3Synthesis and Biological Evaluation of Heterocycle-Fused Pyxinol Derivatives as Anti-osteoporosis Agents2025 · 3 citations
4Synthesis and Evaluation of a Novel Series of Diphenylamine and Diphenylether Derivatives with Osteoblastogenic and Osteogenic Effects <i>via</i> CDK8 Inhibition2024 · 4 citations
5Discovery of novel cathepsin K inhibitors for osteoporosis treatment using a deep learning-based strategyOriginal Research · 2025 · 6 citations

More related papers

Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K2023
Design and Synthesis of α-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis2010
An Efficient Synthesis of Novel Aminothiazolylacetamido-Substituted 3,5-Bis(arylidene)-4-piperidone Derivatives and Their Cytotoxicity Studies2024

More from Molecules

DES-Based Strategies for Agri-Food By-Product Valorization and Emerging DES–Lipase Systems for Mycotoxin MitigationThu,
Interfacial Charge Transport Engineering in MoO3 via Integration of PEDOT:PSS for Efficient and Durable Oxygen Evolution ReactionThu,