Case series reports virologic failure during long-acting rilpivirine and cabotegravir therapy in HIV-1 infection, highlighting the utility of therapeutic drug monitoring.
Virologic failure of long-acting rilpivirine/cabotegravir is rare but may result in severely limited treatment options. Known risk factors cannot predict all cases. Therapeutic drug monitoring (TDM) may help identify patients at risk, but reliable thresholds are missing. We report retrospective TDM in a cohort of 5 patients, including 1 virological failure.
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Gerstenberg et al. (2024) studied this question.
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