Animal model study demonstrates impaired skeletal development following presenilin-1 disruption in pigs, highlighting novel porcine systems for Alzheimer's disease research.
Presenilin 1 (PSEN1) is one of the genes linked to the prevalence of early onset Alzheimer's disease. In mice, inactivation of Psen1 leads to developmental defects, including vertebral malformation and neural development. However, little is known about the role of PSEN1 during the development in other species.
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