Preclinical study demonstrates that CpG oligonucleotides induce acute thrombocytopenia in mice, indicating critical roles for toll-like receptor 9 and spleen tyrosine kinase signaling.
CpG oligonucleotides (ODNs) are synthetic single-stranded DNA sequences that act as immunostimulants. They have been increasingly used to treat several cancers; however, thrombocytopenia is a potential recognized side effect of some sequences.
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Johansson et al. (2024) studied this question.
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