Observational study reveals links between fecal deoxycholic acid, diet, and gut microbes in primary sclerosing cholangitis, highlighting metabolic roles in chronic liver disease progression.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with a strong association with inflammatory bowel disease and variable disease progression. We aimed to gain insights into the role of fecal bile acids (BA) on disease progression by determining the relationships between fecal BA, diet, and gut microbes, with markers of disease progression, BA synthesis, and farnesoid X receptor (FXR) activity.
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Chan et al. (2024) studied this question.
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