Malondialdehyde-specific natural IgM inhibit NETosis triggered by coronary extracellular vesicles of myocardial infarction patients

Acute myocardial infarction (MI) and associated mortality and morbidity remains a major health care challenge.Patients after acute MI remain at high risk for subsequent ischemic cardiovascular events, despite optimized medical management, including intense lipid lowering 1 .Immunothrombosis drives a substantial proportion of this residual risk, and first immunemodulating secondary preventive therapies have recently proven effective in reducing cardiovascular events in clinical studies. 2,3To further refine such approaches, advanced