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Experimental analysis reveals exacerbated cisplatin-induced acute kidney injury driven by Hippo effector TAZ in tubular cells, highlighting a novel target for renal protection.
Transcriptional coactivator with PDZ-binding motif (TAZ), a Hippo signaling pathway effector, maintains the balance of cell proliferation, differentiation, and death. However, the role of TAZ in tubular cell survival and acute kidney injury (AKI) remains largely unknown.
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Xue et al. (2024) studied this question.
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