An International, Prospective Registry of CytoSorb® Hemoadsorption Therapy in Critically Ill Patients: Rationale and Protocol of the COSMOS Registry (Preprint)

Extracorporeal blood purification with CytoSorb has been increasingly used as an adjunctive therapy in several hyperinflammatory critical care conditions, as well as to remove elevated levels of myoglobin or bilirubin in patients with rhabdomyolysis or liver failure. Despite the increasing worldwide use of hemoadsorption, data from large international multicenter studies are still lacking.