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August 16, 2024Synfacts

General Methodology for the α-Alkylation of Cyclic Ketones

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Abstract

Key words α-alkylation - Grignard reagents - organocopper - hydrogenation - piperidines - pyrrolidines - late-stage functionalization

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Cite This Study

A 2024 study studied this question.

synapsesocial.com/papers/68e5bfacb6db643587557922 https://doi.org/10.1055/s-0043-1775049

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Toward a Chemical Constructor: A Lego-Like Approach for Formal α-Alkylation of Cyclic Ketones2024 · 3 citations
2Enantioselective α-Alkylation of Enolizable Ketones with Alkyl Iodides under Bimetallic Nickel Catalysis2024
3Nickel‐Catalyzed Enantioselective α‐Allylation of Cyclic Ketones with Allylic Alcohols2024 · 4 citations
4Synergistic Copper‐Aminocatalysis for Direct Tertiary α‐Alkylation of Ketones with Electron‐Deficient Alkanes2024 · 4 citations
5Stereoselective α-Benzylation of Cyclic Ketones via Chemoenzymatic Cascade2024

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Asymmetric α-C(sp3)–H Allylic Alkylation of Primary Alkylamines by Merging Iridium and Ketone Catalysis2024
Recent Advances in Saturated N-Heterocycle C–H Bond Functionalization for Alkylated N-Heterocycle Synthesis2024
Copper-Catalyzed C(sp3)–H Alkylation of Glycine Derivatives2024

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