⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

August 15, 2024NatureOpen Access

Structure of a fully assembled γδ T-cell antigen receptor

Benjamin S. Gully João Ferreira Fernandes Sachith D. Gunasinghe Mai Tuyet Vuong Yuan Lui Michael T. Rice Liam Rashleigh Chan-Sien Lay Dene R. Littler Sumana Sharma Ana Mafalda Santos Hariprasad Venugopal Jamie Rossjohn Simon J. Davis

View Full Paper

Ask AI

Bookmark

Share

Abstract

T cells in jawed vertebrates comprise two lineages, αβ T cells and γδ T cells, defined by the antigen receptors they express-that is, αβ and γδ T cell receptors (TCRs), respectively. The two lineages have different immunological roles, requiring that γδ TCRs recognize more structurally diverse ligands

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Gully et al. (2024) studied this question.

synapsesocial.com/papers/68e5c0e5b6db6435875587d2 https://doi.org/10.1038/s41586-024-07920-0

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Structural characterization of two full length γδTCR/CD3 complexes2024
2γδ T cell receptor dependencies define a unique immunosurveillance modalityOriginal Research · 2026
3Structure and specificity of T cell receptor gamma/delta on major histocompatibility complex antigen-specific CD3+, CD4-, CD8- T lymphocytes.Original Research · 1988 · 224 citations
4Deep Sequencing of the Human TCRγ and TCRβ Repertoires Suggests that TCRβ Rearranges After αβ and γδ T Cell CommitmentOriginal Research · 2011 · 141 citations
5&gamma;&delta; T Cells Link Innate and Adaptive Immune ResponsesOriginal Research · 2005 · 305 citations