This process demonstrates an innovative coupling reaction with acylsilanes and allylic alcohols, highlighting nucleophilic carbenes and functional-group tolerance.
A palladium-catalyzed and photoinduced coupling reaction between acylsilanes and allylic alcohol derivatives based on the reactions of nucleophilic siloxycarbenes, generated via the light-induced isomerization of the corresponding aroyl-, heteroaroyl-, alkenoyl-, or alkanolysilanes, with electrophilic π-allylpalladium complexes was developed. The dual activation by light and Pd(0) enables the coupling to proceed at temperatures below ambient temperature with a broad substrate scope and high functional-group tolerance.
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Masuda et al. (2025) studied this question.
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