Electrochemical approach generates α-acyloxyketones from diarylethanones, indicating sustainable pathways.
A divergent electrochemical transformation of diarylethanones using molecular oxygen and electricity as green oxidants provides a sustainable and scalable strategy for synthesizing α-acyloxyketone compounds. Mechanistic studies reveal bromide-mediated generation of a benzyl radical cation intermediate, which undergoes divergent reaction pathways: (i) anodic oxidation to a benzyl cation or (ii) reaction with cathodically generated O2•- followed by Baeyer-Villiger oxidation to a carboxylate anion.
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Zhuang et al. (2025) studied this question.
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