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October 8, 2025Leukemia & lymphoma/Leukemia and lymphoma

Venetoclax plus hypomethylating agents versus priming regimen as the first-line therapy for newly diagnosed acute myeloid leukemia with myelodysplasia-related changes: a propensity score-matched analysis

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Authors

YHYuan-Hong HuangUniversity of Science and TechnologyFLFang-Tong LiuLiaoning University of Traditional Chinese MedicineCWChao‐Ling WanSoochow University

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Implication

Retrospective analysis shows that venetoclax improves overall remission and survival in AML-MR patients, highlighting its potential as a first-line therapy.

Key Points

  • VEN+HMA treatment achieved a significantly higher overall remission rate compared to priming regimens.
  • The overall survival for patients receiving VEN+HMA was significantly better than for those using priming regimens.
  • Multivariate analysis confirmed that VEN+HMA was an independent predictor of higher remission rates and survival.
  • These findings indicate that VEN+HMA may serve as a preferred low-intensity induction therapy for AML-MR.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1ba6950a706b22b5342https://doi.org/10.1080/10428194.2025.2566317
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Venetoclax plus a hypomethylating agent versus cytarabine, aclarubicin, and granulocyte colony‐stimulating factor chemotherapy as a first‐line therapy for newly diagnosed acute myeloid leukemia: A propensity score–matched analysis2024 · 4 citations
  2. 2Long‐term follow‐up of VIALE‐A : Venetoclax and azacitidine in chemotherapy‐ineligible untreated acute myeloid leukemia2024 · 229 citations
  3. 3Allogeneic hematopoietic stem cell transplant overcomes poor prognosis of acute myeloid leukemia with myelodysplasia-related changes2015 · 18 citations
  4. 4Acute myeloid leukemia ontogeny is defined by distinct somatic mutations2014 · 1,005 citations
  5. 5Poor prognostic implications of myelodysplasia-related mutations in both older and younger patients with de novo AML2023 · 42 citations