Synthesis, in silico and in vitro studies of aminopyrimidine hybrids as EGFR TK inhibitors and anti-proliferative agents

Q: What type of study is this?

This is a In Vitro Study study (also classified as: Experimental Study).

Wael Shehta; Basant Farag; Shaker Youssif; Samar El‐Kalyoubi; Sherin M. Elfeky

doi:10.1039/d5ra02524a

January 1, 2025RSC AdvancesOpen Access

Synthesis, in silico and in vitro studies of aminopyrimidine hybrids as EGFR TK inhibitors and anti-proliferative agents

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Key Points

Compounds 6c and 10b demonstrated strong EGFR-TK inhibition and anti-proliferative effects against MCF-7 cells.
In silico studies indicated that these compounds are safe and have good oral bioavailability for potential use.
The successful synthesis of two pyrimidine hybrid series showcases their potential as drug candidates.
Docking studies confirmed that these compounds bind effectively to the EGFR-TK target, enhancing their therapeutic potential.

Implication

Synthesis of pyrimidine hybrids reveals anti-proliferative effects and EGFR TK inhibition, suggesting potential therapies.

Abstract

Two pyrimidine hybrid series (6a–g, 10a–d) were synthesized. Compounds 6c and 10b showed anti-proliferative activity against MCF-7, strong EGFR-TK inhibition, and docking confirmed effective binding. In silico studies suggest safe, orally bioavailable candidates.

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Cite This Study

Shehta et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1ba6950a706b22b5457 https://doi.org/10.1039/d5ra02524a

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Synthesis, in silico and in vitro studies of aminopyrimidine hybrids as EGFR TK inhibitors and anti-proliferative agents

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis, in silico and in vitro studies of aminopyrimidine hybrids as EGFR TK inhibitors and anti-proliferative agents

Key Points

Implication

Abstract

Discussion

Cite This Study

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