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October 8, 2025Archiv der Pharmazie3 citations

Recent Developments in Pharmacological Outcomes of Synthetic Triazoles: A Comprehensive Review

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DADivyakshi AryaFSFarmeena ShafaqSSShweta Singh

Key Points

  • Triazoles exhibit notable pharmacological outcomes such as antifungal and anticancer properties, and they play a critical role in medicinal chemistry.
  • The review discusses various synthetic methods, particularly emphasizing click chemistry, that enhance the development of triazole derivatives.
  • Heterocyclic compounds like triazoles are increasingly significant in drug discovery and are relevant to many biological functions.
  • Synthetic triazoles are gaining traction in different fields, including organic synthesis and supramolecular chemistry, indicating their multi-faceted applications.

Abstract

ABSTRACT Recent research has shown that heterocyclic compounds and their derivatives have garnered a great deal of attention in medicinal chemistry due to their noteworthy biological and pharmacological characteristics. A characteristic of both natural products and pharmaceutical drugs is the triazole nucleus which is one of the most significant heterocycles. Most pharmaceuticals include large amounts of heterocyclic nitrogen. One of the preferred structural motifs of triazoles, among nitrogen‐containing heterocyclic compounds, has drawn a lot of interest from both academia and industry. Triazoles are widely used in organic synthesis, supramolecular chemistry, polymer chemistry, drug discovery, chemical biology, bioconjugation, fluorescence imaging, and materials research. Additionally, this intriguing heterocycle's many biological functions will be covered. Researchers, particularly those paying attention to the development of triazole derivatives with a number of synthetic methods—particularly the well‐liked click chemistry approach—and their pharmacological outcomes such as antifungal, antitubercular, antibacterial, antiviral, and anticancer properties will find this review highly significant.

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Cite This Study

Arya et al. (2025) studied this question.

synapsesocial.com/papers/68e5c1ba6950a706b22b5506https://doi.org/10.1002/ardp.70103
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