Collective Synthesis of Indole‐Derived Natural Products via Halogen Bond Donor Catalysis: Efficient Access to Arundine, Turbomycin B, and Arsindoline A Through 3,3′‐Bis(Indolyl)methane Assembly

Halogen bonding, a directional and tunable non‐covalent interaction, has recently gained attention as a sustainable alternative to hydrogen bonding in organic synthesis. Herein, we introduce a novel and sustainable halogen bond‐driven strategy for the synthesis of 3,3′‐bis(indolyl)methane (BIM) derivatives, employing carbon tetrabromide (CBr₄) as a halogen bond donor in acetonitrile. This metal‐free protocol operates under mild conditions, offering high efficiency, broad substrate scope, and excellent yields. By applying this method, we successfully synthesized BIMs, that closely resemble naturally occuring bioactive molecules such as arundine, turbomycin and arsindoline, highlighting the potential medicinal relevance of this approach.