Disease overview demonstrates chronic pulmonary infection in hyper IgE syndrome, highlighting impairment of pulmonary innate host defense.
Hyper IgE syndrome (STAT3-HIES), also known as Job's syndrome, is a rare immunodeficiency disease typically caused by dominant-negative STAT3 mutations. STAT3-HIES syndrome is characterized by chronic pulmonary infection and inflammation, suggesting impairment of pulmonary innate host defense.
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Sun et al. (2024) studied this question.
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