A fast, scalable, transition metal-free, electrochemical sp2 geminal functionalization of carbonyls enabled by anodic oxidation of non-prefunctionalized chromone-fused indolizines to access the triarylmethanes (TRAMs) is disclosed for the first time. This momentary electrochemical approach features the use of readily available carbonyls, implantation of the C(sp3) center (well-known for dramatically improving biological active potency), a broad substrate scope, and excellent yields of TRAMs with fluorescence properties.
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Jat et al. (2024) studied this question.
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