IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells

Yi Zhang; Miso Park; Lucy Ghoda; Dandan Zhao; Melissa Valerio; Ebtesam Nafie; Asaul Gonzalez; Kévin Ly; Bea Parcutela; Hyeran Choi; Xubo Gong; Fang Chen; Kaito Harada; Zhenhua Chen; Le Xuan Truong Nguyen; Flavia Pichiorri; Jianjun Chen; Joo Y. Song; Stephen J. Forman; Idoroenyi Amanam; Bin Zhang; Jie Jin; John C. Williams; Guido Marcucci

doi:10.1186/s13045-024-01586-x

Ask about this paper

Answers are grounded in this paper and cite their sources.

Abstract

The interleukin-1 receptor accessory protein (IL1RAP) is highly expressed on acute myeloid leukemia (AML) bulk blasts and leukemic stem cells (LSCs), but not on normal hematopoietic stem cells (HSCs), providing an opportunity to target and eliminate the disease, while sparing normal hematopoiesis. Herein, we report the activity of BIF002, a novel anti-IL1RAP/CD3 T cell engager (TCE) in AML.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e5c449b6db64358755a5c4 https://doi.org/10.1186/s13045-024-01586-x

View Full Paper

Ask AI

Bookmark

Share

IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells

Ask about this paper

Abstract

Discussion

Cite This Study

IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells

Ask about this paper

Abstract

Discussion

Cite This Study

Keep reading

Keep reading