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August 14, 2024Journal of Biological ChemistryOpen Access

Differential utilization of vitamin B12-dependent and independent pathways for propionate metabolism across human cells

Harsha Gouda Yuanyuan Ji Sneha Rath David Watkins David S. Rosenblatt Vamsi K. Mootha Jace W. Jones Ruma Banerjee

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Abstract

Propionic acid links the oxidation of branched-chain amino acids and odd-chain fatty acids to the TCA cycle. Gut microbes ferment complex fiber remnants, generating high concentrations of short chain fatty acids, acetate, propionate and butyrate, which are shared with the host as fuel sources. Analysis of vitamin B

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Cite This Study

Gouda et al. (2024) studied this question.

synapsesocial.com/papers/68e5c449b6db64358755a7c3 https://doi.org/10.1016/j.jbc.2024.107662

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