Rejecting or retaining motion corrupted transients in diffusion-weighted MRS: high b-values and multiple directions

Robust processing is crucial for a reliable microstructural interpretation of advanced diffusion-weighted magnetic resonance spectroscopy (DW-MRS) methods. The spectral signal intensity depends on the direction when using strong diffusion-gradients and multiple directions, even more if the voxel content is very anisotropic (e.g. contains a white matter tract). In this study we propose a model-based way of identifying motion corrupted averages that accounts for the voxel anisotropy.