Comparison of Magnetic Resonance Spectroscopy Data Acquired with Hybrid PET-MRI and Standalone MRI Scanners

Magnetic resonance spectroscopy (MRS) is a powerful tool for quantifying metabolite concentrations, but spectral quality has not been thoroughly explored in hybrid MRI scanners. Using repeated measurements in a brain phantom and healthy volunteer, we determined the reproducibility and accuracy of MRS data on two systems, a hybrid GE PET-MRI (3.0 T) and Siemens 3.0 T MRI. Spectra acquired using the PET-MRI scanner produced metabolite concentrations with higher accuracy and lower variance across repeated measurements compared to the standalone MRI, suggesting spectral quality is not hindered by the hybrid system.