Quantification of myelination in Children with Attention-deficit/hyperactivity Disorder: A Comparative Assessment with Synthetic MRI and DTI

Evaluation of myelin content is crucial for attention-deficit/hyperactivity disorder (ADHD) and other neurodevelopmental disorders. Diffusion tensor imaging (DTI) is a usual tool to assess white matter structural change in ADHD but it’s indirectly. Synthetic MRI–based (SyMRI-based) method, as a suitable quantitative technique, can investigate myelin content through quantifying whole-brain myelin volume fraction (MVF) and myelin volume (MYV). We aim to evaluate myelin estimation using SyMRI–based method and compared it with established DTI metrics in ADHD children.