Towards accurate and repeatable 1mm isotropic whole-brain MRF quantification using a 1-minute scan with optimized processing pipeline

A rotation-fitting based PV reduction pipeline with B0, B1+ and frequency-based flip angle (FA) scaling corrections are proposed to improve the accuracy and repeatability of magnetic resonance fingerprinting (MRF) in the existence of motion. 5 repeated scans from both stable baseline and big motion positions were acquired and analyzed to compare the repeatability of MRF under different rotation-fitting schemes and B0, B1+ corrections. Rotation before the fitting can substantially reduce the PV effects. The B0/ B1+ and frequency-based FA scaling corrections improve the estimation accuracy. The 2min and 1min 1mm3 whole brain MRF quantitative results also indicate a high repeatability.