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Discriminating Cognitive Impairment and Alzheimer's Disease is challenging due to overlapping subtle structural changes and cognitive variations. Load and distribution of white matter hyperintensity across brain regions may elicit structural atrophy and cognitive disabilities via continuous vascular insult. Here, we have investigated the kinetics and regional distribution of White matter hyperintensity with aging and its implications in brain structure and cognitive health using T2-FLAIR and T1w longitudinal MRI from the NACC cohort.
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Gupta et al. (2024) studied this question.
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