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Heart failure with preserved ejection fraction (HFpEF) characterized by heart diastolic dysfunction. Epicardial adipose tissue (EAT) has been speculated to play an important role in HFpEF pathophysiological processes. In present study, EAT volume was significantly increased in patients with HFpEF and patients with high risk for developing HFpEF compared with healthy controls, and it was correlated with CMR parameters indicative of diastolic dysfunction, particularly GLS and LA reservoir, conduit, and pump strains. These findings provided compelling evidence for the potential role of EAT in adverse myocardial remodeling and the pathophysiology of HFpEF.
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Li et al. (2024) studied this question.
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