Geometric mean T2 of the intra/extracellular water can help identify diffusely abnormal white matter in multiple sclerosis

Diffusely abnormal white matter (DAWM) is seen on 25-50% of conventional brain MRI scans from all stages of multiple sclerosis (MS). From 8 advanced MRI metrics, geometric mean T2 of the intra/extracellular water (IET2) best separated MS participants with and without DAWM. Comparing IET2 to controls using z-scores, regions with an intermediate increase in IET2 (z-scores between 1-2) may identify DAWM voxels.