Brain water-content based Electrical Properties Tomography in healthy volunteers, tumor and multiple sclerosis patients

In this work, we first extend the validation of the water-content based Electrical Properties Tomography (wEPT) model from brain white matter to gray matter conductivity reconstructions in healthy volunteers. Secondly, we show that wEPT reconstructions calibrated on 10 healthy volunteers from an MR-STAT clinical trial dataset show a conductivity increase in pathological regions for 6 primary brain tumor and 9 multiple sclerosis (MS) patients from the same study. For diffuse glioma, a positive correlation between grade and conductivity is observed. For MS white matter lesions a clear conductivity increase is observed compared to healthy white matter.