Longitudinal stability of brain and spinal cord structural quantitative MRI measures

The stability of quantitative MRI measures of microstructure in the brain and spinal cord was quantified longitudinally over three years. Six healthy subjects were scanned approximately four times per year with an structural quantitative imaging protocol (T1w, T2w, T2*w, DWI, MP2RAGE, MTsat, and B1). The intra-subject COV indicated good stability of all quantitative metrics measured in the brain (< 2.3% in WM, < 3.1% in GM). The spinal cord resulted in slightly higher COVs (3.9% - 9.5%). This work is part of a larger project, the Courtois project on neural modelling (CNeuroMod).