Brain Age Prediction using optimized MRI Brain Features: A novel strategy to understand Aging and Aging Associated Pathologies

A certain subset of the aging population maintains the cognitive abilities with minimal structural changes with aging while another subset of people transforms to mild cognitive impairment and dementia with manifold structural variations. Since a subset maintains the cognitive abilities, brain structural volume with aging while another subset undergoes cognitive-impairment and drastic brain structure alterations, we believe that the brain age pattern is distinct from chronological age. Here, we have used a set of MRI determined brain volumetry to determine the brain age as a measure of normal and pathological aging.