The goal of our study was to correlate quantitative digital microscopic histological markers of hepatic steatosis with MRI-PDFF and demonstrate that microenvironment characterization can be used to evaluate hepatic microstructure in NAFLD for future MRI-based studies. Patients were recruited to undergo weight loss surgery during which a liver biopsy was performed. The biopsies were analyzed for steatosis proportionate area (SPA) and characterization of fat droplets. The SPA strongly correlated to the pathologist grading and MRI-PDFF and the liver fat content strongly correlated with the number of fat droplets. Our work demonstrated the feasibility of using MRI to characterize liver microstructure.
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Joshi et al. (2024) studied this question.
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