CEST and MISL detect regional neuropathologies in a Parkinson’s disease mouse model at 3T

Reveal alterations in molecules and CSF-tissue water exchange could enable interactive interventions in PD. Here we applied CEST and MISL to study the changes in a PD model at 3T. We observed significant changes (P<0.05) at 2.6ppm on day 28 and at -3.5ppm on day 7, which could indicate a substantial decrease of dopamine and lipid-related pathology at the substantia nigra, respectively. Along the nigrostriatal pathway, we observed a gradual MISL drop at the ventricles, which was significantly lower at day 28 (P<0.05) and might imply the CSF-tissue-related pathologies. Our findings could serve as potential biomarkers for early PD detection.