Feasibility of Prostate MR Fingerprinting and ADC Mapping in the quantitative characterization of malignant transition zone lesions

The purpose of this study is to assess the feasibility of the use of MR Fingerprinting combined with ADC mapping for characterizing prostate transition zone (TZ) cancers. This quantitative approach has shown promising results in differentiating prostate cancer from normal prostate tissue in peripheral and transition zones, and in separating low from intermediate/high grade tumors in the PZ. Our study aimed to confirm previous observations of quantitative differences in T1, T2 and ADC between cancers and normal appearing TZ, and to assess the utility of MRF-derived T1 and T2 mapping in distinguishing low grade lesions from high/intermediate-grade cancers in TZ.