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The functional alteration of the substantia nigra (SN), basal ganglia (BG), thalamus, and cortex are key hallmarks of Parkinson’s disease (PD) patients. Based on resting state functional magnetic resonance imaging, we investigated the functional connectivity (FC) of “cerebello-SN-BG-thalamo-motor cortical” network in the conventional and slow-4, slow-5 bands. PD patients demonstrated extensive FC decrease at conventional band, including inter-network connections of thalamo-cerebello-BG circuits, and connections between SN-putamen and postcentral gyrus-cerebellum. Slow-4 showed more thalamo-BG changes, while slow-5 specific FC was mainly the "cerebello-SN-BG-thalamo" circuits. The frequency specific alterations in motor related circuits may help in understanding the neuropathological mechanisms of PD.
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Zhang et al. (2024) studied this question.
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