Clinical significance of leakage corrected hemodynamic parameters computed from DCE-MRI on quantitative glioma grading

Absolute quantification of cerebral-blood-volume (CBV) and cerebral-blood-flow (CBF) from dynamic-susceptibility-contrast (DSC)-MRI has shown wide clinical applications. Recent developments in dynamic-contrast-enhanced (DCE)-MRI have shown computation of CBV and CBF along with permeability information with and without model dependent analyses. The model free approach computed CBV and CBF with inherent leakage information and it is still unclear about the clinical significance of leakage correction. So this study is designed to evaluate the impact of leakage correction of CBV and CBF into glioma grading. Results of the study shows that leakage correction underperformed in terms of noise sensitivity and quantitatively differentiating glioma.