The ASL Challenge Reproduction Study: Replicating Findings from The OSIPI-ISMRM ASL MRI Challenge

While the recommendation for ASL acquisition is widely adopted to standardize quantification of cerebral blood flow (CBF), ASL analysis still produces wide variability in CBF estimates. The recent OSIPI-ISMRM ASL MRI Challenge highlighted how differences in image processing contribute to CBF variability. Here, we explored the replicability of ASL image processing approaches when used as documented to quantify CBF. The results of 5 of the 8 ASL Challenge teams were replicated and compared to their submitted results. The overall errors in global mean CBF were 0.03-5 times larger in the replicated results, demonstrating the need for ASL analysis standards.