Signal Amplification By Reversible Exchange in Shields Enable Alignment Transfer to Heteronuclei (SABRE-SHEATH) was employed to boost 15N magnetic resonance sensitivity on common anti-cancer agents. The SABRE-SHEATH hyperpolarization dynamics of letrozole and anastrozole were independently optimized with respect to solution temperature and polarization transfer field. These studies enabled single scan 15N detection of the drugs at natural isotopic abundance working with mM concentrations for over 30 minutes, paving the way for more sensitive drug development.
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MacCulloch et al. (2024) studied this question.
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