Dependence of PDFF Measurement Accuracy on Location, Resolution, and Field Strength – a Phantom Experiment

The purpose of this work was to determine the spatial dependence of PDFF measurements at both 1.5T and 3.0T in a phantom setting. We showed that bias in CSE-MRI-based PDFF measurements is low when performed in areas not more than 20 cm from the isocenter in any direction. These results have immediate practical relevance for clinical routine, e.g., in prescribing MRI acquisitions for clinical PDFF measurements and for the correct placement of pocket phantoms in the MRI bore when used as quality assurance tools.