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Largely neglected due to its low concentration, yet brain glycogen plays an active role in brain energy metabolism and may be involved in a variety of brain diseases. The application of 13C MRS along with 13C-glucose intravenous infusion is to date the forefront method for investigating brain glycogen metabolism in vivo. Notably, the C1-resonances of glycogen and glucose have been detected non-invasively in the conscious human brain by 13C MRS at 4T after 13C-glucose infusion labelled at the C1-carbon. In this study, we explore the potential of 13C MRS at 7T with broadband 1H-decoupling towards measuring glycogen and glucose C1-resonances.
Eulalia Serés Roig (Wed,) studied this question.