Intra-arterial chemotherapy following blood-brain barrier opening (BBBO) can be a highly effective therapeutic delivery mechanism when treating primary and metastatic disease in the brain. Osmotic blood-brain barrier disruption has long been performed under x-ray guidance but has yet to gain clinical traction partially due to outcome variability. MRI is advantageous for its superior soft tissue contrast and real-time perfusion territory validation. We propose a passive microcatheter to provide real-time feedback of catheter positioning during BBBO under MRI guidance. In a phantom, we quantitated susceptibility artifacts at 3T. The catheter showed promise as a new MRI-visible tool to enhance BBBO procedures.
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Kilbride et al. (2024) studied this question.
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