Guanidinium CEST (GuanCEST) and amideCEST are highly sensitive to pH change, while their correlations with pH are opposite. Thus taking (unitless) difference of GuanCEST and amideCEST provides a reliable indicator for pH. Polynomial and Lorentzian line-shape fitting (PLOF) method helps extract the two CEST signals precisely, and the (unitless) difference shows a significant increase (p=0.008, n=10) in Alzheimer’s disease (AD) mouse brain compared with that of wild type mouse at 3T. Our results light up a novel and promising method to detect the onset of AD noninvasively, bringing the recent breakthrough in AD mechanism to further clinical application.
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Wang et al. (2024) studied this question.
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