Effects of MR-Guided Focused Ultrasound Pallidotomy on Dyskinesia and Cerebral Regional Homogeneity in Parkinson’s Disease

MR-guided Focused Ultrasound (MRgFUS) pallidotomy is a promising, non-invasive neurosurgical approach for treating the primary and secondary symptoms, such as levodopa-induced dyskinesia, of Parkinson’s Disease (PD). While the behavioral effects of MRgFUS pallidotomy in PD have been previously established, its impacts on brain circuity and how these changes relate to symptom resolution are currently unclear. In the current study, we compared measures of Regional Homogeneity (ReHo), a metric of spatiotemporal correlation thought to reflect the integrity and modularity of mesoscopic circuity, before and after FUS lesion of the Globus Pallidus internus (GPi).