Feasibility study reveals elevated positive susceptibility values in ALS patients at 7T MRI, highlighting in-vivo iron accumulation during motor cortex neurodegeneration.
The in-vivo imaging of iron and myelin concentrations of the motor cortex in amyotrophic lateral sclerosis (ALS) patients has significance in advancing knowledge about the degeneration progress of the disease. Here, we explored the feasibility of applying 𝜒-separation to ALS patients in-vivo at 7T. When the susceptibility values in hand knobs are examined, ALS patients have higher positive susceptibility values than healthy controls, confirming the histological finding of iron accumulation in ALS.
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Kim et al. (2024) studied this question.
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