This is the first study to use a bi-tensor free water imaging to evaluate microstructural changes in deep gray matter (DGM) nuclei of Wilson’s disease (WD). Despite the shortcomings our study manifested that free water imaging detects microstructural alterations in both normal and abnormal appearing DGM nuclei of WD patients. Correlations between free water imaging indices and neurological impairment in WD patients were also noticed. Therefore, as a promising tool, free water imaging deserves further investigation in longitudinal studies to evaluate its role in monitoring disease onset, progression, and treatment efficacy in WD patients.
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Jing et al. (2024) studied this question.
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