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Post traumatic brain injury (TBI) neuroinflammation has been linked to many long-term outcomes of TBI. To better understand the interrelationship of the neuroinflammation and changes of functional connectivity, we followed rats after TBI in a series of functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) experiments. We observed hypoconnectivity in the corticothalamic connections, which was laterally altered at the acute time point and correlated with the observed level of neuroinflammation in the lateroposterior thalamic nuclei. This sheds light on the potential role of focal post-traumatic neuroinflammation shaping large scale functional connectivity in the post-traumatic brain.
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Dvořáková et al. (2024) studied this question.
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