Theoretical justification for fluid-suppressed APTw imaging based on spillover correction principles

Fluid suppression has an inestimable value in improving the readability of Amide Proton Transfer weighted imaging in the neuro-oncological field, by removing contamination effects in the fluid compartments. With this work we wanted to justify the derivation of this metric and to show different clinical examples. Our new fluid-suppressed APTw metric for 3T MR imaging, based on the principles of Spillover Correction for CEST imaging, can be then derived through the Bloch McConnell Equations.