MRI phenotypes of the brain are related to long-term dementia outcome in community-dwelling older adults

This is the authors' abstract. We don't add key points for this paper.

Individual brain MRI markers only show at best a modest association with long-term occurrence of dementia. Therefore, it is challenging to accurately identify individuals at increased risk for dementia. We implemented a combined hierarchical clustering analysis based on neurodegenerative and neurovascular brain MRI markers and identified 14 distinct subgroups of individuals with different brain MRI phenotypes. These subgroups had a different long-term risk for dementia; especially the multi-burden brain MRI phenotype showed an increased risk (HR: 13.8 (95%-CI:4.28-44.37)). These findings may in the future be useful to determine patient prognosis and may aid in patient selection for future treatment studies.