Effect of isocaloric ketogenic diet on fat content in the liver and muscle and volume of adipose tissue

The effect of a 28-day isocaloric ketogenic diet followed by a 2-day carbohydrate realimentation on adipose tissue and fat content in the liver and calf muscle in 22 obese women was studied using MRS and MRI methods. During the ketogenic diet, there was a significant decrease in liver fat volume (69±20 ml, i.e. decrease 43±4% of basal value) and liver fat content (2.7±0.6 %, i.e. 35±5% of basal value) and reduction cross-section in both subcutaneous (6 %) and visceral (7 %) fat. Contrary, the intramyocellular fat increased during the diet.