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In quantitative DSC-MRI, the concentration-time course is obtained from the MR signal changes following a bolus injection of contrast agent. The generally assumed linear relationship between ΔR2* and contrast agent concentration is not always valid. In this study a realistic 3D simulation model was used to establish the characteristics of this relationship in whole-blood and brain tumor tissue. The results show an improved performance of the 3D simulation model compared to its 2D version. In addition, the relationship between ΔR2* and contrast agent concentration appeared to be dependent on the B0 direction and MR sequence.
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Dorth et al. (2024) studied this question.
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